Injectable Hydrogel System for the Treatment of Stroke and Nervous Tissue Injury


Over 1.7 million Americans in the US sustain traumatic brain injury (TBI) each year[1] and an estimated 3.2 million Americans have long term disabling effects from TBI[2].  This novel and effective technology features an injectable biomaterial gel with the ability to promote functional tissue regeneration at the site of a traumatic brain injury and stroke. The technology provides a procedure whereby the hydrogel is injected into a lesion in the brain that will direct the response of neural stem cells in the brain to regenerate normal brain tissue at the lesion site. This technology provides a potential alternative, beneficial approach to the current methods used to treat traumatic brain injuries which focus on managing the primary injury using hypothermia or neuro-protection with pharmacological agents.  Research using this material has demonstrated revascularization of the lesion sites and sustained recovery in rats with CNS injuries. 


· Traumatic Brain Injury Repair

· Repair of brain lesions due to stroke

· Repair of spinal cord lesions


· Injectable, acellular therapy that recruits native cells and promotes functional tissue regeneration 

· Alternative approach to current methods used to treat traumatic brain injuries that employ hypothermia or neuroprotection with pharmacological agents


Inventors:                        Ning Zhang, Xuejun Wen

Protection Status:           Patent application filed

Licensing Status:            Available for licensing

Additional Terms:          Hydrogel, Extracelluar Matrix Molecules, Stroke, Traumatic Brain Injury (TBI), Spinal Cord Injury

CURF Ref No:                08-049


[1] (2010)

[2] (2010)


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Patent Information:
Biomedical Sciences
For Information, Contact:
Chris Gesswein
Director of Licensing
Clemson University Research Foundation
Xuejun Wen
Ning Zhang
Medical Device
Stem-Cell Engineering
Tissue Engineering
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