Search Results - biomaterials+-+cardiovascular

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Myocardial In Vitro Platform for Drug Development and Cardiotoxicity Screening

This myocardial in vitro screening platform provides relevant physiological stimuli enabling analysis of output metrics with direct clinical relevance to cardiac function. While drug discovery is robust and well-funded, a very low percentage of experimental drug candidates reach the marketplace as FDA-approved therapies. This translates into billions...

Published: 1/11/2024 | Inventor(s): William Richardson, Samuel Coeyman, Jonathan Heywood

Keywords(s): Analytical/Diagnostics/Instru./Sensors-Medical/Biological, Biomaterials - Cardiovascular, Cardiovascular, Diabetes, Drugs/Pharma - Antibiotics, Drugs/Pharma - Drug Delivery, Drugs/Pharma - HIV/Cancer/Other, Medical Device, Molecular Therapies, Oncology/Cancer, Regenerative Medicine, Tissue Engineering

Category(s): Biomedical Sciences

Improved Fixation Method for Bioprosthetic Heart Valves

Bioprosthetic Heart Valves can replace defective or diseased heart valves, but a majority of these valves fail within a few years due to calcification and degeneration. Currently used methods of fixation, such as glutaraldehyde crosslinking, are not adequate to fix all extracellular matrix components, especially glycosaminoglycans (GAGs) present in...

Published: 9/16/2020 | Inventor(s): Narendra Vyavahare, Devanathan Raghavan

Keywords(s): Biomaterials - Cardiovascular, Medical Device

Category(s): Biomedical Sciences

New Material for Transcatheter Bioprosthetic Heart Valves

This technology features a biomaterial useful for bioprostheses, such as bioprosthetic heart valves (BHVs), in which the fixed tissue has improved elastic properties. The high elastin-containing biomaterial is further characterized by having anisotropic properties wherein the biological material has a greater stiffness in one direction and a greater...

Published: 1/5/2024 | Inventor(s): Narendra Vyavahare, Dan Simionescu

Keywords(s): Biomaterials - Cardiovascular, Medical Device

Category(s): Biomedical Sciences

Elastogenic Effects of Hyaluronan Oligosaccharides and Their Applications in Tissue Engineering (includes 07-054)

Elastin is a critical component in all connective tissue and is not readily regenerated by the body. In order to develop or regenerate functional connective tissue, elastogenic cues to synthesize, organize, and stabilize the extracellular matrix are critical.The invention includes novel elastogenic cues for injured or developing connective tissues (i.e....

Published: 1/5/2024 | Inventor(s): Anand Ramamurthi, Chandrasekhar Kothapalli, Binata Joddar

Keywords(s): Biomaterials - Cardiovascular, Medical Device, Tissue Engineering

Category(s): Biomedical Sciences