Search Results - Molecular Therapies

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Elastin Targeted Drug Delivery for Treating Elastin Degenerative Diseases (2012-048)
This targeted drug delivery approach uses micro-sized drug carriers with elastin antibodies that recognize, attach, and deliver compounds to prevent enzymatic degradation of elastin in diseased tissue. Enzymatic degradation of elastin tissue is the primary cause of chronic obstructive pulmonary disease (COPD) and abdominal aortic aneurysm (AAA). CO...
Published: 9/13/2016   |   Inventor(s): Narendra Vyavahare, Aditi Sinha
Keywords(s): Biomaterials, Cardiovascular, Cardiovascular Biomaterials, Drugs / Pharma, Medical Device, Molecular Therapies, Nanoscale Drug Delivery, Regenerative Medicine
Category(s): Biomedical Sciences
Injectable Joint Lubricant for Treating Osteoarthritis (00-001)
This dextran-based hydrogel uses phospholipid delivery to treat degenerative joint diseases, also known as osteoarthritis. Osteoarthritis is the most common type of arthritis, affecting over 27 million Americans over the age of 25. It becomes more common with age, often affecting the neck, lower back, knees, and hips. Normally synovial fluid, a nat...
Published: 9/8/2016   |   Inventor(s): Julie-Ann Burdick, Martine Laberge, Gary Lickfield
Keywords(s): Biomaterials, Medical Device, Molecular Therapies, Orthopaedic Mechanics, Tissue Engineering
Category(s): Biomedical Sciences
Topical Application of Hydrogel for the Treatment of Acute Spinal Cord Injury (2011-072)
This hydrogel can be used for the non-invasive treatment of acute spinal cord injuries by applying topically to the injury site. According to the Centers for Disease Control and Prevention, about 450,000 people in the United States are currently living with a spinal cord injury and 12,000 new cases develop each year. The cost of rehabilitation and ...
Published: 7/12/2016   |   Inventor(s): Xing Jin, Vibhor Krishna, Xuejun Wen, Ning Zhang
Keywords(s): Biomaterials, Drugs / Pharma, Molecular Therapies, Regenerative Medicine, Tissue Engineering, Treatment Method
Category(s): Biomedical Sciences
Peptide for Improved Neural Stem Cell Growth (2012-051)
This peptide introduces a new way to accelerate cell growth of neural stem cells in culture. The global stem cell market is expected to grow from $6.7 billion in 2016 to nearly $12.3 billion in 2021, representing a thriving market. Cultured cells, especially stem cells, struggle to effectively proliferate on their own. Currently, peptide chains suc...
Published: 7/12/2016   |   Inventor(s): Xiaowei Li, Ning Zhang, Xuejun Wen
Keywords(s): Biomaterials, Drugs / Pharma, Molecular Therapies, Regenerative Medicine, Stem-Cell Engineering, Treatment Method
Category(s): Biomedical Sciences
Bioprosthetic Heart Valves that Resist Structural Degradation and Stiffening (2013-055)
This treatment stabilizes the connective tissue present in bioprosthetic heart valves to create durable and long-lasting replacement heart valves. There are approximately 300,000 heart valve transplantations performed globally each year and heart valve disorders are diagnosed in approximately four million people. There are major problems with the t...
Published: 6/3/2016   |   Inventor(s): Narendra Vyavahare, Hobey Tam
Keywords(s): Cardiovascular Biomaterials, Molecular Therapies
Category(s): Biomedical Sciences
Stable Antibacterial Albumin Coating for Medical Devices and Implants
Healthcare-Associated Infections (HAIs) characterized by antibiotic resistance, represent a global medical challenge tha claims billions of dollars of healthcare expenditures. Procedures involved tubes inserted into the body (i.e. catheterization) are among the primary causes of HAIs. Presented here is a stable antibacterial coating for intubation...
Published: 1/17/2013   |   Inventor(s): Igor Luzinov, Xuejun Wen, Suraj Sharma, Ben Whatley
Keywords(s): Biomaterials, Biomaterials Implant Design, Coatings, Medical Device, Molecular Therapies
Category(s): Biomedical Sciences
Treatment to Render Implants Resistant to Diabetes
Diabetes plays a role in the functionality of biomaterials in the body. Hyperglycemia, the condition arising from high blood sugar levels, causes occlusion and restenosis of vascular grafts and degeneration of heart valves. These conditions lead to heart disease, which made up 68% of all diabetes-related deaths in the U.S. in 2004[1]. A primary ...
Published: 1/17/2013   |   Inventor(s): Agneta Simionescu, Dan Simionescu, James Chow
Keywords(s): Biomaterials, Biomaterials Implant Design, Cardiovascular Biomaterials, Drugs / Pharma, Medical Device, Molecular Therapies, Regenerative Medicine
Category(s): Biomedical Sciences
Elastogenic Effects of Hyaluronan Oligosaccharides and Their Applications Thereof in Tissue Engineering (includes 07-054)
Elastin is a critical component in all connective tissue and is not readily regenerated by the body. In order to develop or regenerate functional connective tissue, elastogenic cues to synthesize, organize, and stabilize the extracellular matrix are critical.The invention includes novel elastogenic cues for injured or developing connective tissues ...
Published: 12/15/2009   |   Inventor(s): Anand Ramamurthi, Chandrasekhar Kothapalli, Binata Joddar
Keywords(s): Biomaterials, Cardiovascular Biomaterials, Medical Device, Molecular Therapies, Tissue Engineering
Category(s): Biomedical Sciences
Deposition of Nanocrystalline Calcite on Metal Alloys by a Cellular Biomineralization Means and process for Preparing Same
These technologies feature a method for deposition of nano-crystalline calcite plates by specialized epithelial tissue or cells onto metallic surfaces, such as stainless steel or other alloys. This is the first demonstration of a novel crystalline material that is produced by animal tissues which can be produced in a highly controlled process. This...
Published: 12/15/2009   |   Inventor(s): Andrew Mount, Neeraj Gohad, Douglas Hansen, Karolyn Hansen, MaryBeth Johnstone
Keywords(s): Molecular Therapies, Nanotechnology, Tissue Engineering
Category(s): Biomedical Sciences
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