Search Results - biomedical+sciences

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Myocardial In Vitro Platform for Drug Development and Cardiotoxicity Screening

This myocardial in vitro screening platform provides relevant physiological stimuli enabling analysis of output metrics with direct clinical relevance to cardiac function. While drug discovery is robust and well-funded, a very low percentage of experimental drug candidates reach the marketplace as FDA-approved therapies. This translates into billions...

Published: 10/8/2024 | Inventor(s): William Richardson, Samuel Coeyman, Jonathan Heywood

Keywords(s): Analytical/Diagnostics/Instru./Sensors-Medical/Biological, Biomaterials - Cardiovascular, Cardiovascular, Diabetes, Drugs/Pharma - Antibiotics, Drugs/Pharma - Drug Delivery, Drugs/Pharma - HIV/Cancer/Other, Medical Device, Molecular Therapies, Oncology/Cancer, Regenerative Medicine, Tissue Engineering

Category(s): Biomedical Sciences

Exhaled Breath-Based Test for Ammonia

Chronic kidney disease (CKD), a condition in which a patient’s kidneys fail to effectively filter blood, is estimated to affect more than one-in-seven Americans placing a significant burden on the US healthcare system costing Medicare over $120 billion in 2017. Commonly called the "silent disease," CKD presents with no symptoms in its...

Published: 10/8/2024 | Inventor(s): Riley Rapert, Robert Latour, George Chumanov, Sudha Garimella, Tyler Harvey, Guzeliya Korneva

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Category(s): Biomedical Sciences

Ibrutinib as a potential therapeutic for cocaine use disorder (CUD)

Ibrutinib utilized as a treatment for cocaine use disorder (CUD) can be used as a neuroprotective effect against cocaine toxicity. According to the National Survey on Drug and Health, almost 1 million people in the United States are affected by CUD and 13% of patients in North American substance-use facilities are treated for CUD. However, there...

Published: 10/8/2024 | Inventor(s): Robert Anholt, Trudy MacKay

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Category(s): Biomedical Sciences

Delivery and Attachment Systems for Repairing Reherniated Intervertebral Discs

These mechanical attachments systems can help repair discectomy patients’ reherniated intervertebral disc (IVD) post-surgery and promote natural tissue healing. Nearly 400,000 discectomies are performed each year in the US to remove herniated IVD tissue fragments. However, reherniation is the most common complication from these surgeries, which...

Published: 10/8/2024 | Inventor(s): Jeremy Mercuri, Richard diMonda, Matt Pursley, Ishmael Bentley

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Category(s): Biomedical Sciences, Advanced Materials

Highly Rare Earth Doped Optical Fiber & Heating Element Comprising Same

This highly rare earth doped optical fiber and heating element is superior to traditional methods, allow for the absorption of light for biomedical and microfluidic applications. According to Allied Market Research, the global optical fiber market was valued at $3,477 million in 2017, and is projected to reach $8,153 million by 2025, growing at a CAGR...

Published: 10/8/2024 | Inventor(s): John Ballato, Courtney Kucera, Matthew Tuggle, Peter Dragic, Andrey Mironov

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Category(s): Biomedical Sciences

Novel Compounds for Treatment of Parasitic Infections

African Trypanosomiasis, also known as “sleeping sickness,” is caused by microscopic parasites transmitted to humans by the Tsetse fly, found in rural Africa. It is a serious public health problem in sub-Saharan Africa, with around 10,000 new cases each year. This serious disease is fatal if left untreated, however, the currently available...

Published: 10/8/2024 | Inventor(s): Daniel Whitehead, James Morris, Chandima Narangoda

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Category(s): Biomedical Sciences

High Performance Optical Sensor for Unity Confinement of Light

This wave-guide biosensor comprised of a multilayer porous silicon (pSi) nanomaterial near 100% (unity) confinement of light using a simple inverse processing technique for high performance, low cost porous silicon photonics. The global market for biosensors is projected to reach $20.7 billion USD by 2020, driven by the emergence of new technologies,...

Published: 10/8/2024 | Inventor(s): Judson Ryckman, Gabriel Allen, William Delaney, Tahmid Talukdar

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Category(s): Biomedical Sciences

Improved Fixation Method for Bioprosthetic Heart Valves

Bioprosthetic Heart Valves can replace defective or diseased heart valves, but a majority of these valves fail within a few years due to calcification and degeneration. Currently used methods of fixation, such as glutaraldehyde crosslinking, are not adequate to fix all extracellular matrix components, especially glycosaminoglycans (GAGs) present in...

Published: 10/8/2024 | Inventor(s): Narendra Vyavahare, Devanathan Raghavan

Keywords(s): Biomaterials - Cardiovascular, Medical Device

Category(s): Biomedical Sciences

Crosslinked free fatty acids for use in antibacterial medical device implants

FFA-based biomaterials created via this novel crosslinking process have significant opportunity for application in medical device implants. The global market for medical device coatings is expected to reach $7.9 billion in 2021. However, common materials for these coatings, such as stainless steel, titanium, and Teflon, often provoke an aggressive immune...

Published: 10/8/2024 | Inventor(s): Andrew Tennyson, Rhett Smith

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Category(s): Biomedical Sciences

Capillary-Channeled Polymer Fibers for Isolating Exosomes

This capillary-channeled polymer (C-CP) fiber technology is a cost efficient and highly selective method to isolate exosomes facilitating widespread use of these cellular fragments for biomarker research, medical diagnostics, and targeted delivery of therapeutics. Exosomes are lipid membrane-derived vesicles secreted by most types of cells, which hold...

Published: 10/8/2024 | Inventor(s): Richard Marcus, Terri Bruce, Lei Wang, Sisi Huang, Tyler Slonecki, Rhonda Powell

Keywords(s): Analytical/Diagnostics/Instru./Sensors-Medical/Biological, Bioprocessing/Biotechnology, Drugs/Pharma - Drug Delivery

Category(s): Advanced Materials, Biomedical Sciences

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