Search Results - medical+device

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Myocardial In Vitro Platform for Drug Development and Cardiotoxicity Screening

This myocardial in vitro screening platform provides relevant physiological stimuli enabling analysis of output metrics with direct clinical relevance to cardiac function. While drug discovery is robust and well-funded, a very low percentage of experimental drug candidates reach the marketplace as FDA-approved therapies. This translates into billions...

Published: 10/8/2024 | Inventor(s): William Richardson, Samuel Coeyman, Jonathan Heywood

Keywords(s): Analytical/Diagnostics/Instru./Sensors-Medical/Biological, Biomaterials - Cardiovascular, Cardiovascular, Diabetes, Drugs/Pharma - Antibiotics, Drugs/Pharma - Drug Delivery, Drugs/Pharma - HIV/Cancer/Other, Medical Device, Molecular Therapies, Oncology/Cancer, Regenerative Medicine, Tissue Engineering

Category(s): Biomedical Sciences

Improved Fixation Method for Bioprosthetic Heart Valves

Bioprosthetic Heart Valves can replace defective or diseased heart valves, but a majority of these valves fail within a few years due to calcification and degeneration. Currently used methods of fixation, such as glutaraldehyde crosslinking, are not adequate to fix all extracellular matrix components, especially glycosaminoglycans (GAGs) present in...

Published: 10/8/2024 | Inventor(s): Narendra Vyavahare, Devanathan Raghavan

Keywords(s): Biomaterials - Cardiovascular, Medical Device

Category(s): Biomedical Sciences

Multi-Needle Roller for Cell Seeding

Seeding cells within scaffolds or tissues hold great potential for regenerative medicine projects. Until now, cells have been either placed on top of scaffolds, creating multiple layers of superficial cells, or injected manually with a syringe inside the tissues, generating large boluses of cells. None of these approaches generated the homogenous, high...

Published: 10/8/2024 | Inventor(s): Dan Simionescu, Benjamin Fisher, Harrison Smallwood

Keywords(s): Bioprocessing/Biotechnology, Medical Device, Regenerative Medicine, Tissue Engineering

Category(s): Biomedical Sciences

New Material for Transcatheter Bioprosthetic Heart Valves

This technology features a biomaterial useful for bioprostheses, such as bioprosthetic heart valves (BHVs), in which the fixed tissue has improved elastic properties. The high elastin-containing biomaterial is further characterized by having anisotropic properties wherein the biological material has a greater stiffness in one direction and a greater...

Published: 10/8/2024 | Inventor(s): Narendra Vyavahare, Dan Simionescu

Keywords(s): Biomaterials - Cardiovascular, Medical Device

Category(s): Biomedical Sciences

Smart Orthopedic Screws for Imaging through Tissue

These smart orthopedic screws allow physicians to noninvasively detect and monitor the health of bone implants, potentially preventing infection and implant loosening over time. In the United States, musculoskeletal injuries affect over 28 million patients annually – at least two million of which require fracture fixation surgery. These surgeries...

Published: 10/8/2024 | Inventor(s): Jeffrey Anker, Jonathan Heath, Dakota Anderson, Melissa Rogalski

Keywords(s): Bioinstrumentation, Biomaterials - Orthopaedic, Medical Device, Orthopaedics - Orthotics/Prosthetics/Hardware/Other

Category(s): Biomedical Sciences

Durable Polymeric Antimicrobial Coating for Orthopedics

External fixation is a well-established orthopedic practice in which fractured bones or fusion sites are immobilized for healing by placing wires and/or pins into the bone on either side. Unfortunately, both superficial and deep tissue infections are prevalent with the use of external fixators, particularly Staphylococcal infections. The economic burden...

Published: 10/8/2024 | Inventor(s): Alexey Vertegel, Igor Luzinov, Christopher Gross, Dmitry Gil, Nikolay Borodinov

Keywords(s): Biomaterials - Orthopaedic, Coatings, Medical Device, Orthopaedics - Orthotics/Prosthetics/Hardware/Other

Category(s): Biomedical Sciences

Biphasic Osteochondral Construct for Cartilage Tissue Repair

This osteochondral construct is seeded with mesenchymal stem cells to encourage repair of cartilage and subchondral bone in synovial joints. The global market for tissue engineering and regeneration is expected to grow from $13.6 billion in 2016 to $60.8 billion in 2021, in part due to the 5.4 million patients projected to require joint and cartilage...

Published: 10/8/2024 | Inventor(s): Karen Burg, Scott Maxson

Keywords(s): Biomaterials - Orthopaedic, Medical Device, Orthopaedics-Biologics/Tissue Engr/Regen Medicine, Tissue Engineering

Category(s): Biomedical Sciences

Inherently Omniphobic Fibers and Fabrics

This fiber modification uses channels with re-entrant features in the shape of repeating trapezoids to create highly repellent textiles that resist attraction of both water and liquid chemicals, solvents, and oils. The self-cleaning textiles market, which includes hydrophobic, oleophobic, and omniphobic materials, is expected to reach a value of $573...

Published: 10/8/2024 | Inventor(s): Philip Brown, Quoc Truong, Nicole Hoffman

Keywords(s): Medical Device, Textiles/Fibers - Non-Optical/Medical/Other

Category(s): Advanced Materials, Biotechnology

Organic Fluorophores for More Efficient Plastic Scintillators (2016-019)

These organic fluorophores have enhanced luminosity in response to ionizing radiation, increasing the efficiency of plastic scintillators and providing greater environmental stability. With increasing investments in radiation monitoring for homeland security, the scintillator market is expected to reach $607.21 Million by 2025. Currently available plastic...

Published: 10/8/2024 | Inventor(s): Valery Bliznyuk, Ayman Seliman, Timothy Devol, Nadezhda Derevyanko, Alexander Ishchenko

Keywords(s): Analytical/Diagnostics/Instru./Sensors-Medical/Biological, Medical Device, Optical Fibers/Materials/Other

Category(s): Advanced Materials

Injectable Joint Lubricant for Treating Osteoarthritis

This dextran-based hydrogel uses phospholipid delivery to treat degenerative joint diseases, also known as osteoarthritis. Osteoarthritis is the most common type of arthritis, affecting over 27 million Americans over the age of 25. It becomes more common with age, often affecting the neck, lower back, knees, and hips. Normally synovial fluid, a natural...

Published: 10/8/2024 | Inventor(s): Julie-Ann Burdick, Martine Laberge, Gary Lickfield

Keywords(s): Biomaterials - Other, Drugs/Pharma - Drug Delivery, Medical Device, Tissue Engineering

Category(s): Biomedical Sciences

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