Latest technologies from Clemson University Research Foundationhttp://curf.technologypublisher.comBe the first to know about the latest inventions and technologies available from Clemson University Research Foundationen-USWed, 17 Jul 2019 19:29:46 GMTMon, 01 Jul 2019 11:29:16 GMT 2019, Clemson University Research FoundationCapillary-Channeled Polymer Fibers for Isolating Exosomes capillary-channeled polymer (C-CP) fiber technology is a cost efficient and highly selective method to isolate exosomes facilitating widespread use of these cellular fragments for biomarker research, medical diagnostics, and targeted delivery of therapeutics. Exosomes are lipid membrane-derived vesicles secreted by most types of cells, which hold promise for diagnosing disease, as they retain the biomarkers of their parent cell. By analyzing exosomes, the presence of diseased cells may be detected prior to clinical onset of chronic diseases. Currently available methods of exosome isolatio...Mon, 01 Jul 2019 11:29:16 GMTcontactcurf@clemson.edu microtissues to model infarction injury and methods preparing and using the same OverviewThese cardiac microtissues mimic the presentation of infarct injuries in individuals with cardiovascular disease, such as heart attack or stroke, allowing for a model to study pathogenesis and drug development for injuries caused by cardiovascular disease. Cardiovascular disease is the leading global cause of death, accounting for more than 17.6 million deaths in 2016. While incidences of cardiovascular disease are on the rise globally, human organoid systems have largely focused on modeling genetic disease, rather than tissue-level pathology, such as heart attack or stroke. Thi...Wed, 22 May 2019 08:22:17 GMTcontactcurf@clemson.edu Fixation Method for Bioprosthetic Heart Valves heart valves (BHVs) are used clinically to replace defective or diseased heart valves, but a majority of these valves fail within a few years due to calcification and degeneration. Currently used methods of fixation, such as glutaraldehyde crosslinking, are not adequate to fix all extracellular matrix components, especially glycosaminoglycans (GAGs) present in the middle spongiosa layer. This technology presents methods for improving the structural and mechanical characteristics of implantable tissue as well as methods for increasing the lifespan of the implantable tissue. Applic...Thu, 02 May 2019 10:49:01 GMTcontactcurf@clemson.edu Hydrothermal Crystal Growth that Eliminates Spontaneous Emission (2011-108) hydrothermal approach to growing single crystal oxide hosts resolves the issues posed by amplified spontaneous emission (ASE). ASE is the result of unwanted internal reflection of photons at the lasing frequency within the laser crystal. The consequences of ASE include induced emission of ions from the excited state and unwanted internal lasing in random directions. These effects take away the needed amount of power from the laser and severely inhibit the performance of the lasers. From an economic standpoint, the global market for solid state lasers is projected to steadily increase, rea...Wed, 06 Feb 2019 10:00:32 GMTcontactcurf@clemson.edu<![CDATA[Film Vessels for Heterotrophic & Photoautotrophic Growth & Acclimation]]> plant propagation apparatus is disclosed which comprises a flexible transparent enclosure. The enclosure is disposable and could be formed of a polymer such as polyethylene. The enclosure would have at least two walls formed of a flexible material that facilitates transmission of light through the walls. Plant material is sealed within the enclosure, and a nutrient solution is made available within the sealed enclosure for the plant. The enclosure is a low cost and effective method for propagating young plants and transporting them between the laboratory environment and a greenhouse or field...Mon, 04 Feb 2019 08:16:53 GMTcontactcurf@clemson.edu Roller for Cell Seeding cells within scaffolds or tissues hold great potential for regenerative medicine projects. Until now, cells have been either placed on top of scaffolds, creating multiple layers of superficial cells, or injected manually with a syringe inside the tissues, generating large boluses of cells. None of these approaches generated the homogenous, high cells density constructs with cells distributed in 3D that could be used as tissues for patients. Therefore, there is a need for a device capable of efficiently seeding cells into scaffolds or tissues at multiple locations with high efficacy. Cl...Mon, 07 Jan 2019 11:05:24 GMTcontactcurf@clemson.edu Material for Transcatheter Bioprosthetic Heart Valves technology features a biomaterial useful for bioprostheses, such as bioprosthetic heart valves (BHVs), in which the fixed tissue has improved elastic properties. The high elastin-containing biomaterial is further characterized by having anisotropic properties wherein the biological material has a greater stiffness in one direction and a greater elasticity in a cross direction. This technology can be used to improve current BHV devices which have a short lifespan due to mechanical deterioration and biological degeneration, due to the lack of elasticity of the tissues. This technology offer...Mon, 31 Dec 2018 08:53:45 GMTcontactcurf@clemson.edu Image Digitizer to Improve Agricultural GIS spatial image digitizer (SID) provides not only normalized difference vegetation index (NDVI) data with true color imagery but can also indicate soil texture variability. From 2017 to 2018 there is a forecasted nearly twelve percent drop in farming net income in the U.S., making 2018 forecasted to have the lowest net income in over eight years. This decrease in net income will affect over two million farms in the U.S. with over 850,000 employees. Clemson University researchers have developed a spatial image digitizer (SID) to help farmers with growing crops and increase yields. The SID te...Wed, 26 Sep 2018 08:42:20 GMTcontactcurf@clemson.edu the Composite Manufacturing Process Through Folding, 26 Sep 2018 07:15:40 GMTcontactcurf@clemson.edu Self-Healing Copolymers, 25 Sep 2018 12:00:14 GMTcontactcurf@clemson.edu Carbon Dots for Optical Imaging, 24 Sep 2018 10:18:00 GMTcontactcurf@clemson.edu Aquaculture Ecosystem for Managing Wastewater aquaculture ecosystem utilizes low RPM paddlewheels to control water flow rate and feed fish waste to algae to reduce eutrophication effects. For every ton of fish produced as much as 66 kilograms of nitrogen waste and 10.5 kilograms of phosphorus waste are produced. The waste feeds plankton and algae, and in excess can lead to blooms and then eutrophication and dead zones. Researchers have developed a method for reducing fish waste output using algal growth basins originally developed for wastewater treatment. In tests the Partitioned Aquaculture System (PAS) farmed catfish as the target...Mon, 24 Sep 2018 08:25:50 GMTcontactcurf@clemson.edu Cutter System for Plant Tissue Culture (2016-045), 19 Sep 2018 09:47:09 GMTcontactcurf@clemson.edu Osteochondral Implant for Enhanced Bone Healing novel off-the-shelf osteochondral implant exhibits a highly similar microarchitecture to that of native bone and cartilage, allowing better integration and mechanical support to the damaged tissue after implantation. Approximately 2,000,000 surgical procedures were performed to repair chondral defects in the United States between 2004-2011, with a 5% annual incidence growth over that time period. Osteoarthritis presents a monumental societal burden. It was responsible for $185.5 Billion in aggregate annual expenditure in the United States alone in 2008. Symptomatically, approximately 27 m...Wed, 19 Sep 2018 06:58:32 GMTcontactcurf@clemson.edu Orthopedic Screws for Imaging through Tissue (2012-018), 21 Aug 2018 08:48:19 GMTcontactcurf@clemson.edu Donors for Environmental Remediation using Rendered Animal Co-Products, 10 Aug 2018 08:07:57 GMTcontactcurf@clemson.edu Wireless Sensor (2017-027) novel, self-powered sensor technology enables wireless transmission over a range of tens of meters without a motor or active power supply. The smart sensor market is expected to grow from 18.58 billion USD in 2015 to 57.77 billion USD by 2022, with the wireless sensor market share expected to reach over $940 million by 2020. However, all commercially available wireless sensors in the market require a power source. Clemson University researchers have developed a portable, self-powered wireless sensor that can be adapted to many applications such as smart electrochromic screens, security al...Tue, 13 Mar 2018 10:37:19 GMTcontactcurf@clemson.edu, surfactant-free polymerization of amphiphilic block copolymers in water (2016-015), 20 Feb 2018 09:58:56 GMTcontactcurf@clemson.edu Composite Materials for Construction Applications (2017-025) composites chemically combine abundant agricultural and petrochemical wastes, allowing for practical reduction of inert wastes that can be used to either supplement or replace traditional construction materials. Approximately 7 million tons of waste sulfur and 5 million tons of waste lignocellulose are produced each year. Only a quarter of these sulfur wastes are utilized, while little to none of the lignocellulose wastes are used for other purposes. Clemson University researchers have created a method of using these wastes in a way that not only is environmentally friendly, but also inc...Tue, 20 Feb 2018 09:10:44 GMTcontactcurf@clemson.edu Polymeric Antimicrobial Coating for Orthopedics (2017-059) fixation is a well-established orthopedic practice in which fractured bones or fusion sites are immobilized for healing by placing wires and/or pins into the bone on either side. Unfortunately, both superficial and deep tissue infections are prevalent with the use of external fixators, particularly Staphylococcal infections. The economic burden caused by treating such infections is expected to reach $1.6B annually by 2020. Though other antimicrobial coatings have been developed for use in orthopedics, the process required to insert the hardware into the patient exerts a tremendous she...Thu, 08 Feb 2018 13:37:17 GMTcontactcurf@clemson.edu, Biocompatible Nanomaterials for Multiphoton Imaging (07-034) biocompatible carbon nanomaterials exhibit luminescence, making them excellent for multiphoton imaging of cells, spores, tissues, and organs in vitro and in vivo. The global microscopy market is expected to continue growing, and is projected to reach $5.8 billion by 2019. In recent years, multiphoton imaging has been favored over traditional ultraviolet (UV) light techniques for their safer and more accurate approach to biological imaging. However, current multiphoton imaging practices use luminescent materials which are not biologically compatible, creating the need for safer materials ...Thu, 01 Feb 2018 10:10:48 GMTcontactcurf@clemson.edu Sensing Device for Direct Signal Processing (2017-009), 16 Jan 2018 08:25:30 GMTcontactcurf@clemson.edu Color Sensitivity for Colorimetric-based Chemical Analysis (2017-055) novel technology for colorimetric chemical analysis significantly enhances color change intensity and uniformity upon exposure to a target substance when compared to conventional color-indicating substrates. This technology thus has application to any colorimetric-based chemical assay, such as urinalysis. The global urinalysis market was estimated to be 1.37 billion USD in 2015 and has only continued to grow since then. As one example for its application, this invention has potential to greatly impact the diagnoses and monitoring of phenylketonuria (PKU), an inborn metabolic disorder that...Tue, 16 Jan 2018 08:04:49 GMTcontactcurf@clemson.edu Microscopy for Live Cell Imaging (2017-048) method of super-resolution microscopy uses subtracted interleaved solid and doughnut-shaped laser pulses to improve spatial resolution, resulting in real-time imaging of live microscopic organisms. The live cell imaging market has an estimated worth of $3.57 billion and is expected to grow due to increased government funding and the demand for high-content screening microscopy techniques in drug discovery. Conventional super-resolution microscopy requires high light dosage or special dyes to achieve improved spatial resolution, which can lead to damage in live cells during the imaging pro...Thu, 11 Jan 2018 10:01:23 GMTcontactcurf@clemson.edu Ceramic Composites for Hydrogen Separation Membranes (2014-127), 06 Nov 2017 10:10:59 GMTcontactcurf@clemson.edu Ceramic/Metal Composite Membrane for Hydrogen Separation (2014-099), 01 Nov 2017 09:59:43 GMTcontactcurf@clemson.edu EDL Capacitor Based Biosensors, 04 Aug 2017 09:13:47 GMTcontactcurf@clemson.edu Growth of Single Crystals for UV Solid State Lasers (2017-002), 20 Apr 2017 08:09:20 GMTcontactcurf@clemson.edu, Biocompatibe MEMS Devices Made From Cellulose (2013-015) cellulose-based film offers a more environmentally friendly and cost-effective alternative to silicon for microelectromechanical systems (MEMS). To date, silicon has been the material of choice for MEMS devices, with a current market of $14 billion that is expected to grow to $20 billion by 2020. However, silicon MEMS have significant disadvantages. Silicon is facing increasing supply constraints and is generally regarded as expensive and environmentally detrimental due to energy intensive processing with harsh chemicals. To overcome the disadvantages of silicon, Clemson University and Au...Mon, 10 Apr 2017 07:03:44 GMTcontactcurf@clemson.edu Nanotube Composite for Use in Conductive MEMS Devices (2016-031) composite, made of multi-walled carbon nanotubes (MWNT) and cellulose nanocrystals (CNC), provides a safer substitute for silicon in microelectromechanical system (MEMS) devices. The global MEMS market was $11.9 billion in 2015, and is expected to grow to $18 billion by 2020 due to increased interest in wearable technology and the automotive industry. Traditionally MEMS devices are made out of doped-silicon. However, the use of doped-silicon poses safety, economic and environmental hazards due to high energy costs, particle waste left in the air and use of harmful chemicals in the manufac...Mon, 27 Mar 2017 07:31:00 GMTcontactcurf@clemson.edu Osteochondral Construct for Cartilage Tissue Repair (09-026) osteochondral construct is seeded with mesenchymal stem cells to encourage repair of cartilage and subchondral bone in synovial joints. The global market for tissue engineering and regeneration is expected to grow from $13.6 billion in 2016 to $60.8 billion in 2021, in part due to the 5.4 million patients projected to require joint and cartilage regeneration procedures by 2019 in the United States. Currently, many patients are living with pain caused by osteoarthritis until it progresses to require total joint replacement or they are old enough to become candidates for the surgery. For pa...Thu, 09 Mar 2017 07:54:26 GMTcontactcurf@clemson.edu miR319 gene to Enhance Abiotic Stress Tolerance in Transgenic Plants (2011-026), 08 Mar 2017 08:07:18 GMTcontactcurf@clemson.edu Cost Identification of Small Molecules and Molecular Subunits (2015-045) approach to molecular analysis and genome sequencing consists of a way to identify small molecules or molecular subunits by taking advantage of changes in the electrical double layer chemical potential and current as well as mobility of the analyte within the nanopore. The global markets for personalized medicine and genomic sequencing are expected to increase in the coming years due to technological and research advancements. The genome sequencing market alone is expected to reach a value of $20 billion by 2020. Current technologies only use ionic current signal to identify molecules; ho...Mon, 06 Mar 2017 07:46:44 GMTcontactcurf@clemson.edu Nano-Object Software for Biomolecular Modeling (2013-020) Protein Nano-Object Integrator (ProNOI) software allows for researchers to generate atomic-style geometrical objects in the desired shape and dimensions either from cry-electron photography or user-specified shape. Biomolecular modeling is important to address biological problems at the molecular level and to understand the interactions between molecules to predict behavior. This is especially useful for pharmaceutical development and within the general research community. Biological macromolecules must frequently be modeled in conjunction with nano-objects in order to understand their in...Wed, 01 Mar 2017 06:58:05 GMTcontactcurf@clemson.edu Omniphobic Fibers and Fabrics (2016-025) fiber modification uses channels with re-entrant features in the shape of repeating trapezoids to create highly repellent textiles that resist attraction of both water and liquid chemicals, solvents, and oils. The self-cleaning textiles market, which includes hydrophobic, oleophobic, and omniphobic materials, is expected to reach a value of $573 million by 2021. Conventional textile surface chemistries rely on chemicals like fluorocarbons, silicones, and waxes to create omniphobic materials. To reduce the need for chemical modifications, researchers from Clemson and the Natick Solider Res...Wed, 01 Feb 2017 06:25:07 GMTcontactcurf@clemson.edu Platform that Enables Large Scale Brain Wave Data Collaboration (2014-081) software platform, EEGnet, provides researchers with an efficient database to view and interact with electroencephalography (EEG) brain wave data. EEG is an electrophysical monitoring system that records electrical activity in the brain and is used most often to diagnose epilepsy. Traditionally, EEG research has been limited due to a lack of large-scale standardized data and inefficient methods for collecting the opinion of large numbers of EEG experts. It is vital to have significant amounts of information in order to validate algorithms regarding EEG data as well as to train novices how...Mon, 23 Jan 2017 08:19:38 GMTcontactcurf@clemson.edu Catheter Tracking System to Reduce Radiation Exposure (2011-122) electromagnetic catheter tracking system improves surgical intervention while reducing radiation exposure to pediatric cardiology patients. As congenital heart disease (CHD) cases continue to rise in children, the pediatric interventional cardiology market is expected rise as well, reaching a value of $1,379.1 million by 2018. While many therapeutic interventions for CHD patients have transitioned from open surgical procedures to minimally invasive, catheter-based procedures requiring fluoroscopic guidance, this approach results in excessive cumulative radiation exposure for children. Acc...Fri, 20 Jan 2017 07:26:26 GMTcontactcurf@clemson.edu Device for Diagnosis and Monitoring of Rotator Cuff Disease (2012-106) device utilizes ultrasound imaging to diagnose and monitor rotator cuff injuries. Each year there are over three million new cases of rotator cuff disease. Among those affected, more than half the population over 60 suffer from rotator cuff disease. Shoulder injuries, and particularly rotator cuff disease, can be difficult to diagnose. To give an accurate diagnosis, one must know the angular force and positional measurements of the shoulder. Current technologies generally give only one of these measurements, and while they can be used in concert with one another, it is difficult to accura...Fri, 20 Jan 2017 06:56:11 GMTcontactcurf@clemson.edu Fixation Device for Treatment of Early Onset Scoliosis and Spinal Deformities (2016-007) rib fixation device attaches expanded titanium hooks on two or four ribs, improving stability of fixation for safer management of upper thoracic instabilities. With early onset scoliosis (EOS) having an incidence of approximately 1-2 per 1000 births, and with frequent complications of originally untreated individuals, care for severe thoracic deformations exceeds an annual $17 billion in costs. Current treatments involve the use of pedicle screws, of which are fixed to the spine itself. However the pedicle screws fixations are subjected to pull-out failure in the presence of kyphosis forc...Fri, 20 Jan 2017 06:40:08 GMTcontactcurf@clemson.edu Biocompatible Hydrogel for Enhanced Hydrophobic Drug Delivery (04-032) hydrogel is tailored during fabrication to release hydrophobic drugs at varying molecular weights to decrease treatment intervals of chronic disorders. The drug delivery market was valued at $1,048.1 billion globally in 2015 and is expected to grow to $1,504.7 billion by 2020, driven by needs for ease of use, proper dosage delivery, and superior spreading ability. Treatments of chronic disorders like diabetes, renal failure, and dwarfism can only be treated with regular dosages of drugs, normally via injection. Regular injection of drugs causes the patient pain and often patient complianc...Tue, 17 Jan 2017 08:00:57 GMTcontactcurf@clemson.edu Enhancement for Plant Insect Resistance (2013-029) cloned soybean cysteine protease inhibitor gene is involved in plant response to biotic stress and its overexpression in plants leads to enhanced insect resistance. Biotic stresses such as destructive pests and plant diseases cause substantial losses in crop yield and quality. In the U.S. alone, pest-related crop losses are estimated at $33 billion annually. While chemical pesticides are used extensively in the United States, use of these pesticides add tremendously to operational costs and raise serious environmental and health concerns. One of the most important targets for enhancing ag...Tue, 17 Jan 2017 07:17:14 GMTcontactcurf@clemson.edu Creeping Bentgrass Plants with Enhanced Stress Tolerance (2014-070) of the miR396c gene in transgenic creeping bentgrass allows for better control of plant flowering and enhances crop performance under adverse environmental conditions. Abiotic stresses such as drought, salt, and nitrogen deficiency are limiting factors for plant growth, development, and agricultural productivity. Therefore, it is critical to develop reliable procedures to genetically modify plants for improved performance under environmental stresses, thereby enhancing agricultural productivity to meet the ever-growing demands in food production. Clemson University researchers h...Tue, 17 Jan 2017 07:08:27 GMTcontactcurf@clemson.edu Promoter for Driving Tissue-Specific Gene Expression in Plants (2014-074) promoter drives constitutive and/or tissue-specific expression of genes in transgenic plants. A promoter is a specific DNA sequence that regulates the expression of downstream coding or other noncoding nucleic acids. As such, promoters are important molecular tools for agricultural biotechnology. There are two main constitutive promoters currently used in transgenic plants, mosaic virus 35S (CaMV 35S) and maize ubiquitin. While strong, these promoters are inefficient in some cases and can cause adverse consequences such as growth suppression. To overcome the shortcomings of current promot...Tue, 17 Jan 2017 06:59:44 GMTcontactcurf@clemson.edu, Self-Healing Coatings (2013-065) self-healing polymer coating inhibits corrosion of metal iron substrates while extending the life of coated materials. Self-healing materials are an emerging and promising market, expected to reach a market value of $2.7 billion by 2020. The concept of self-healing materials is to enable materials to repair damage with minimum intervention. Current approaches to achieving self-healing materials are based on encapsulating self-healing agents, which is an expensive and oftentimes impractical endeavor. Clemson University researchers have developed a self-healable polymeric coating that is ac...Tue, 06 Dec 2016 06:47:41 GMTcontactcurf@clemson.edu Saving Prediction Software for Dual Fuel Energy Conversion Systems (2014-096) predictive software advises vehicle operators on how to maximize their savings by estimating the return on investment and overall cost savings for dual fuel energy conversion devices. According to Navigant Research, dual fuel engine revenue in the United States is expected to reach $58 million by 2024. Dual fuel energy conversion systems continue to rise in popularity as they can displace diesel at a rate of 40-60 percent depending on the load factor and terrain, lowering costs for vehicle operators. Embracing an opportunity for improvement in the field, Clemson researchers have developed...Thu, 22 Sep 2016 07:58:17 GMTcontactcurf@clemson.edu Luminosity Organic Fluorophores for More Efficient Plastic Scintillators (2016-019) organic fluorophores have enhanced luminosity in response to ionizing radiation, increasing the efficiency of plastic scintillators and providing greater environmental stability. With increasing investments in radiation monitoring for homeland security, the scintillator market is expected to reach $479.16 Million by 2020. Currently available plastic scintillators use a polystyrene as the matrix due to its high optical transparency, however, more efficient and inexpensive scintillators are needed for detection of radioactive materials in homeland security, nuclear forensics, and nuclear s...Wed, 21 Sep 2016 08:36:42 GMTcontactcurf@clemson.edu Clip Metal Detector to Aid Breast Surgery (2016-053) handheld metal detector aids surgeons with localizing breast cancers, eliminating the need for invasive procedures. With the increased use of mammographic screening, breast cancer is more frequently detected as a radiographic lesion only rather than a palpable mass. This has made image-directed localization a necessity for surgical excision in a significant proportion of cases. When a patient has an abnormal mammogram, a radiologic breast biopsy is performed and a titanium clip is placed at the biopsy site to mark the site of the cancer. When a patient has a surgical localization procedur...Wed, 14 Sep 2016 09:29:23 GMTcontactcurf@clemson.edu Targeted Drug Delivery for Treating Elastin Degenerative Diseases (2012-048) targeted drug delivery approach uses micro-sized drug carriers with elastin antibodies that recognize, attach, and deliver compounds to prevent enzymatic degradation of elastin in diseased tissue. Enzymatic degradation of elastin tissue is the primary cause of chronic obstructive pulmonary disease (COPD) and abdominal aortic aneurysm (AAA). COPD is the third leading cause of death in the U.S. and there are over 3 million new cases of AAA each year. Currently, damaged elastin is managed via surgical procedures like endovascular surgery. While most procedures are minimally invasive, its lif...Tue, 13 Sep 2016 08:25:21 GMTcontactcurf@clemson.edu Optimization Algorithm Predicts Traffic Signal Information to Improve Fuel Economy (09-073), 08 Sep 2016 09:57:50 GMTcontactcurf@clemson.edu Joint Lubricant for Treating Osteoarthritis (00-001), 08 Sep 2016 09:45:27 GMTcontactcurf@clemson.edu Antioxidant Catalysts for Protection of Artificial Implants (2015-023) artificial implant materials are functionalized with self-regenerating antioxidants which prevent implant degradation. Artificial implants are becoming increasingly popular, with 2 in every 100 Americans having an artificial joint and over 7 million living with total hip or knee replacement. When artificial implants come in contact with the biological tissue, this can trigger an immune response called foreign body reaction (FBR) which results in chemical and mechanical degradation of artificial implants and ultimately implant failure. One method to mitigate the immune response is coating...Tue, 06 Sep 2016 08:53:49 GMTcontactcurf@clemson.edu Biofouling in Water Treatment Membrane Systems (2015-021) approach reduces biofouling by using X-ray irradiation and ultraviolet-emitting materials to reduce bacterial growth and biofilms. Biofouling is a critical issue in membrane water and waste water treatment as it greatly compromises the efficiency of the treatment processes. It is difficult to control and results in increased operational costs and poor performance. Current anti-biofouling techniques involve chemical cleaning steps or antimicrobial surfaces which have proven inadequate over long-term operation for many feed waters. In contrast, Clemson University researchers have developed ...Thu, 01 Sep 2016 11:31:28 GMTcontactcurf@clemson.edu Benzimidazole Derivatives as Antibacterial Drugs (2012-076) bisbensimidazole derivatives are a new family of modified small molecules that are highly selective and effective in preventing bacterial resistance. The market for antibacterial drugs stood at $43.9 billion in 2014, representing a large market for both animals and humans. New approaches for the discovery of antibacterial drugs and antibacterial coatings are important in the fight against bacterial resistance. Bacterial DNA topoisomerases are one class of enzymes that help in regulating DNA topology and are very good targets for the development of anticancer or antibacterial agents. Clem...Thu, 25 Aug 2016 10:06:28 GMTcontactcurf@clemson.edu Friendly, Electro-mechanical Controller for Adjusting Pump Stroke (2016-039), 25 Aug 2016 07:14:46 GMTcontactcurf@clemson.edu HIV Inhibitors to Prevent Spread of Virus in Patients (2010-001) inhibitor comprises a new strategy for mitigating the growth and spread of HIV. According to the World Health Organization, over 36 million people are living with HIV around the world. Consequently, the global HIV therapeutics market is estimated to reach a value of $15.3 billion by 2023. Most HIV inhibitors currently available are nucleoside or reverse transcriptase inhibitors. Increased resistance to these drugs calls for new approaches to HIV suppression, therefore non-nucleoside HIV inhibitors are in demand. Clemson University researchers have developed a new HIV inhibitor featuring t...Thu, 18 Aug 2016 09:27:17 GMTcontactcurf@clemson.edu, Ambient Desorption Optical Emission Spectroscopy for Performing Elemental Analysis (2016-018), 16 Aug 2016 10:17:30 GMTcontactcurf@clemson.edu Chemical Functionality of Nylon C-CP Fibers via Microwave Energy (2016-042), 16 Aug 2016 09:15:03 GMTcontactcurf@clemson.edu of Mammary Tissue for Diagnostic Modeling (2015-056), 13 Jul 2016 08:14:20 GMTcontactcurf@clemson.edu Gas Analyzer for Detecting Resonances (2009-039) resonance frequency detector is capable of detecting a wide variety of parameters affecting resonance through the use of a patented micro-cantilever. This detector modulates electric charge at varying frequencies on a counter electrode until it matches the induced frequency on a cantilever. Current resonance detection devices require piezoelectric or chemically functioned cantilevers or lasers. However these methods require multiple components, are bulky, or have parasitic capacitance. Clemson University researchers have developed a method to detect chemical/biological species and measure...Wed, 13 Jul 2016 07:40:29 GMTcontactcurf@clemson.edu Application of Hydrogel for the Treatment of Acute Spinal Cord Injury (2011-072) hydrogel can be used for the non-invasive treatment of acute spinal cord injuries by applying topically to the injury site. According to the Centers for Disease Control and Prevention, about 450,000 people in the United States are currently living with a spinal cord injury and 12,000 new cases develop each year. The cost of rehabilitation and on-going care can average in the hundreds of thousands of dollars each year, per patient. Unfortunately, there is often no cure for this type of injury; instead, doctors rely on hypothermia and steroid treatments to mitigate the injury and limit the ...Tue, 12 Jul 2016 13:01:27 GMTcontactcurf@clemson.edu for Improved Neural Stem Cell Growth (2012-051) peptide introduces a new way to accelerate cell growth of neural stem cells in culture. The global stem cell market is expected to grow from $6.7 billion in 2016 to nearly $12.3 billion in 2021, representing a thriving market. Cultured cells, especially stem cells, struggle to effectively proliferate on their own. Currently, peptide chains such as laminin or collagen type IV are used to enhance cell proliferation, but these materials are expensive and can trigger immune responses if utilized in the human body. Clemson University researchers have engineered a new chain of peptides that per...Tue, 12 Jul 2016 12:31:35 GMTcontactcurf@clemson.edu Hydrogel for Surgical Repair of High Risk Wounds (2013-056) surgical bioadhesive mitigates the complications associated with traditional suturing practices, potentially decreasing surgery and recovery times. By 2017, the market for high strength medical adhesive is projected to reach $800 million. Clinical need for bioadhesives has risen due to the movement to laparoscopic and minimally invasive surgery over the last decade. Traditionally, sutures are used to close lacerations and stop soft tissue bleeding. Current sutures, however, lack adequate mechanical strength, compliance, and require additional surgical tools. Clemson University researchers...Tue, 12 Jul 2016 11:48:32 GMTcontactcurf@clemson.edu High-Density Functionality of Polymer Surfaces (2015-044) easy modification creates polymer surfaces with high-density functionality by using polyethylene terephthalate (PET) capillary-channeled polymer (C-CP fibers) as the support material. The low-cost modification provides the capability for fast protein separations for proteomics applications and downstream processing due to the improved binding capacity. Protein therapeutics is experiencing phenomenal growth and is poised to reach a market value of $1,463 million by 2020. While this market has seen much improvement and growth in the last decade, the development of high efficiency, low-cost ...Thu, 07 Jul 2016 12:53:55 GMTcontactcurf@clemson.edu Multi-functional Nanotherapeutics for Targeted Drug and Gene Therapy (2014-027) multi-functional polymeric micelle nanocarriers serve as a platform technology for combinatorial delivery of multiple bioactive molecules for the treatment of pathological diseases or repair of injured tissues. With a growing population of cancer patients and the increasing quest for an effective cure, gene therapy represents a $100 billion cancer treatment market. The most commonly used treatment for cancer patients is chemotherapy. However, the efficacy of anticancer drugs has been limited by their toxic side effects in normal cells and drug resistance acquired by cancer cells. Current ...Wed, 22 Jun 2016 07:49:00 GMTcontactcurf@clemson.edu Printed Variable Hardness Foot Orthotics with Patient-Specific Fit (2015-016), 20 Jun 2016 10:51:45 GMTcontactcurf@clemson.edu[PLY]: Sustainable and Eco-friendly Construction Framing (2015-053)[PLY] is a sustainable construction framing system that utilizes pre-manufactured, CNC-cut plywood components and specialized connection details to enable fast, easy, and safe on-site building construction. The market for green, sustainable building materials and construction is trending and on the rise: the global market is projected to reach $529 billion by 2020. Increased awareness about the benefits of green technologies and stricter government regulations are factors that have contributed to the growing market. However, green building practices are still expensive when compared to trad...Thu, 16 Jun 2016 10:28:49 GMTcontactcurf@clemson.edu Purification and Control of Molecular Weight of Lignin (2014-078) renewable solvent system consisting of hot acetic acid-water mixtures can simultaneously purify, fractionate, and solvate lignins. This approach to purifying and controlling the molecular weight of lignin improves the pulping process and its output. Previous processes can be expensive and have poorly controlled molecular or chemical properties. Using traditional methods, less than 0.2 percent of the 50 million tons/yr of Kraft lignin is recovered for use in value-added products because of high ash content and poorly controlled molecular and chemical properties. Clemson University research...Thu, 16 Jun 2016 10:11:55 GMTcontactcurf@clemson.edu Electrolytes for Lithium-Ion Batteries (2014-073) polymer electrolyte for lithium-ion batteries can be used to inhibit thermal hazards associated with large-format and high-power lithium-ion batteries. Batteries and energy storage is an expanding market that is worth tens of billions of dollars annually, with the market for Lithium-Ion batteries expected to hit $30 billion by 2020. Due to this market growth, many research efforts aim to either make lithium-ion batteries larger or designing cells that discharge at faster rates to increase power output. Both these endeavors, however, lead to increased thermal hazards such as fires or explo...Thu, 16 Jun 2016 09:44:04 GMTcontactcurf@clemson.edu Yield Monitor for Round and Square Hay Balers (2015-052) approach to creating crop yield maps results in better management and increased production efficiency on farms. Yield monitoring technologies have been commercially available for corn and grain crops for at least twenty years and have since become stock equipment for most corn, grain, and cotton harvesters. Growers have grown to depend on yield monitors for making and evaluating management decisions, developing management zones, prescribing variable rate input applications, and for evaluating crop insurance values. Currently, hay is among the only major crops that does not have a widely i...Wed, 15 Jun 2016 11:05:21 GMTcontactcurf@clemson.edu PEGylated Amino Acids for Easier Peptide Synthesis (2013-067), 10 Jun 2016 07:58:35 GMTcontactcurf@clemson.edu Double Drill Guide for Use in Arthroscopic Orthopedic Surgery (2015-030) is an orthopedic drill guide accessory that allows surgeons to quickly attach and secure two bone tunnel drill guides to one unit. The American Orthopedic Society for Sports Medicine estimates five million arthroscopic surgeries take place worldwide each year and will continue to increase. The US arthroscopic equipment market accounts for 53 percent of the global market and is estimated at $636 million. With the rise in arthroscopic procedures, surgeons need efficient solutions to reduce surgical time, costs, and number of revision procedures. Many orthopedic procedures require the s...Fri, 03 Jun 2016 09:02:45 GMTcontactcurf@clemson.edu Total Knee Replacement Design for Treating Knee Extensor Weakness (2012-084) design allows patients to selectively lock the knee in full extension for the purposes of ambulation and unlock free rotation when desired. According to the American Academy of Orthopedic Surgeons, over 600,000 total knee replacement surgeries are performed in the United States each year. While total knee replacement (TKR) is a definitive method to restore knee function in most patients, some have trouble with knee function and weakness following surgery. Knee arthrodesis is required when a patient has inadequate muscular control or soft tissue stability to ambulate. This extended positio...Fri, 03 Jun 2016 07:09:31 GMTcontactcurf@clemson.edu Circuit Breaker for Emerging Power Systems (2015-017) circuit breaker naturally distinguishes between a fault on a DC power system and load charges which occur regularly, effectively improving the manufacturing and reliability of DC systems. Many non-traditional energy sources, such as solar panels, fuel cells, and batteries, supply direct-current (DC) power. This has led to development of DC power systems for a number of applications since conversion to alternating-current (AC) can be eliminated. For example, DC distribution is now used for computer data centers, office buildings, and ship power and propulsion. Though the source, loads, and...Wed, 01 Jun 2016 12:54:10 GMTcontactcurf@clemson.edu Hydrogel Material for Combatting Intervertebral Disc Degeneration (2015-048) hydrogel scaffold can be used as an early-stage intervention for combatting intervertebral disc (IVD) degeneration (IDD). Lower back pain is a significant burden that affects nearly 85 percent of all people, 40 percent of which are attributed to IDD. IVDs reside between the bones of the spine and contain the nucleus pulposus (NP) which is a resilient hydrogel core that generates intradiscal pressure to support compressive loading. IDD has been shown to initiate in the NP and results in IVD tissue disorganization, loss of intradiscal pressure and IVD height. Current treatments only mitigat...Wed, 25 May 2016 06:58:06 GMTcontactcurf@clemson.edu Patch to Repair Intervertebral Disc Herniation and Degeneration (2015-050) collagen-based patch is a multi-laminate, ply-angle-ply sheet-based reinforcement used to biologically augment and facilitate repair of the annulus fibrosus (AF) of the intervertebral disc (IVD). Back pain is commonly associated with IVD pathologies including herniation and/or degeneration, resulting in structural defects within the AF. Nearly 500,000 lumbar discectomies are performed annually in the U.S. to aid in alleviating patient pain. During this procedure, a defect is created within the AF to remove herniated/degenerated nucleus pulposus (NP) tissue fragments. The resultant defect ...Tue, 24 May 2016 12:26:53 GMTcontactcurf@clemson.edu Polymers for Pollutant Remediation and Toxin Reduction (2013-054), 23 May 2016 09:23:34 GMTcontactcurf@clemson.edu Production of Single Crystals for Solid State Laser Applications (2013-060), 23 May 2016 06:41:21 GMTcontactcurf@clemson.edu Hydrothermal Growth of Thin Film, Co-Doped Crystals with Optimized Properties for Mass Production (2010-051) alternative approach for growing thin film and co-doped crystals uses hydrothermal techniques that result in optimized crystal qualities, ideal for solid state laser applications. Solid state lasers are used in a wide variety of applications, including the defense, communication, and medical fields. This broad spectrum of uses and the consumer demand for lasers in low-power applications have contributed to a growth in the market, leading to a prediction of a market value of $850 million by 2020. Clemson University researchers created a crystal growth process ideal for solid-state laser ap...Thu, 19 May 2016 13:06:19 GMTcontactcurf@clemson.edu Gradient Doping of Host Crystals for Improved Quality of Solid State Lasers (2011-063) hydrothermal approach provides variation in the concentration of selected dopants within the host single crystal lattice, resulting in improved power and beam quality of solid state lasers. The global market for solid state lasers is projected to steadily increase, reaching $850 million by 2020. This steady growth is primarily due to the demand for lasers with operational thresholds that can be reached at relatively low intensities of laser pumping. One way to achieve low intensities of laser pumping includes varying the laser ion dopant concentration. Existing practices of doing this, ho...Thu, 19 May 2016 12:35:15 GMTcontactcurf@clemson.edu Hydrothermal Growth of High Quality Rhombohedral Crystals (2006-009), 19 May 2016 12:17:13 GMTcontactcurf@clemson.edu Improved Differentiation of Stem Cells into Cardiac Muscle Cells for Cardiac Tissue Repair (2014-091) approach advances the maturation of stem cells or progenitor cells, cells that differentiate like stem cells, to produce functional, biocompatible cardiomyocytes for the repair of damaged cardiac tissue. Cardiomyocytes are specialized cardiac muscle cells essential for cardiac muscle health. Cardiovascular disease, the leading cause of death worldwide, kills one in four Americans annually. A heart attack alone irreversibly destroys one billion cardiomyocytes, which can cause heart failure. Recent research suggests progenitor cells have the potential for regeneration; however attempts to p...Wed, 11 May 2016 12:52:11 GMTcontactcurf@clemson.edu Jet Printing onto Solid Substrata, 08 Jan 2015 11:16:54 GMTcontactcurf@clemson.edu of a DIPEX Coated ZnS:Ag Disk for Quantification of Actinides in Groundwater technology features materials and systems useful in determining the existence of radionuclides in an aqueous sample. The materials provide the dual function of both extraction and scintillation to the systems. The systems are both portable and simple to use and, as such, can beneficially be utilized to determine the presence and concentration of radionuclide contamination in an aqueous sample at any desired location and according to a relatively simple process without the necessity of complicated sample handling techniques. These systems include a one-step process, providing simultaneous ...Tue, 22 Jul 2014 06:31:28 GMTcontactcurf@clemson.edu Portable EPR Sensors invention will be used to exploit electron-paramagnetic-resonance (EPR) as a new approach for rapid diagnostic tests (RDTS) of malaria. The idea is to use RF interference processes to boost EPR sensor sensitivity by more than 103 times for rapid characterization of malaria pigment hemzoin in a single parasitized red-blood-cell (RBC) in blood-plasma. The proposed idea is unconventional because (i) it is a resonator-less method that boosts EPR sensor sensitivity and time-resolution by orders of magnitude with liquid samples, (ii) it enables multi-frequency EPR scheme to significantly enhanc...Fri, 11 Jul 2014 11:41:29 GMTcontactcurf@clemson.edu of Ribbed Polymer Fibers as Stationary/Support Phases for Chemical Separations by Liquid Chromatography or for Waste Stream Remediation, 08 Jul 2014 07:57:32 GMTcontactcurf@clemson.edu Brillouin Optical Fiber that Resists Heat Stress (2012-082), 30 Sep 2013 12:05:21 GMTcontactcurf@clemson.edu Intelligence System for Electric Power Systems, 30 Sep 2013 12:05:19 GMTcontactcurf@clemson.edu Clemson University 15 MW Hardware-in-the-Loop (HIL) Grid Simulator System, 30 Sep 2013 12:05:18 GMTcontactcurf@clemson.edu Stochastic Optimal Power Flow Control for Power Systems with Intermittent Renewable Energy Generation, 30 Sep 2013 12:05:17 GMTcontactcurf@clemson.edu Corrugated Pallet, 26 Sep 2013 13:29:51 GMTcontactcurf@clemson.edu Lipid Modification of Polymer Surfaces to Affect Chemical Reactivity/Selectivity, 23 Sep 2013 13:28:54 GMTcontactcurf@clemson.edu Seams for Fluid, Vapor and Air Barrier Articles, 06 Sep 2013 13:57:18 GMTcontactcurf@clemson.edu Composites for Energy Storage Applications composite material decreases energy storage costs compared to current commercially available technologies. The ability to store intermittent energy from sources such as wind and solar power is a major limitation for the commercial deployment of renewable energies in the consumer market. Currently used materials are not suitable for large-format energy storage due to either cost or safety concerns. However, large-scale energy storage is a rapidly growing market; the United States market saw a nine-fold increase between Q1 2016 and Q1 2017 in terms of deployed megawatt-hours of energy stora...Fri, 06 Sep 2013 13:57:12 GMTcontactcurf@clemson.edu Solid Large Core Photonic Bandgap Fibers for Use in Optical Fiber Lasers, 13 Feb 2013 13:08:12 GMTcontactcurf@clemson.edu Bundle Cartridges as Chemical Separation Media, 23 Apr 2012 11:21:50 GMTcontactcurf@clemson.edu for Probing Hazardous Liquids (2012-024) porous nanofibers are designed to collect extremely small volumes of liquid for analysis, featuring materials that control liquid uptake by a butterfly-type proboscis. The global nanofibers market had an estimated worth of $390.6 million, and is expected to grow at over a 25% CAGR between 2016 and 2024 due to the ever-expanding application space. Sampling of hazardous chemicals or liquids at the cellular level presents a challenge for both safety and sensing capabilities. The ability to deploy, detect, sample, and identify low-volume fluids in a single microfluidics device could be a pro...Mon, 23 Apr 2012 11:21:48 GMTcontactcurf@clemson.edu Silicon Optical Fiber, 08 Nov 2011 08:32:50 GMTcontactcurf@clemson.edu and Material to Extend the Life of Total Joint Replacements through Wear, 13 Jul 2011 08:34:38 GMTcontactcurf@clemson.edu Dioxide Capture in Cement Manufacturing US cement industry produces over 41million metric tons (MMT) of process-related CO2 per year1. That total excludes the CO2 released from the burning of fossil fuel to heat the process. This invention provides a method of capturing much of that CO2 for sale or storage.Using several possible methods, the CO2 may be captured and reintroduced into the system before being captured again and extracted from the system. The initial reuse of the gas influences the production of alite and belite. The alite to belite ratio influences the curing and strength properties of the concrete. Using the CO2 i...Tue, 29 Mar 2011 07:43:28 GMTcontactcurf@clemson.edu Scavengers Comprising a Free Radical Scavenger and a Transition Metal, 29 Mar 2011 07:43:27 GMTcontactcurf@clemson.edu Blending (Chaotic Mixing), 02 Mar 2011 05:57:36 GMTcontactcurf@clemson.edu<![CDATA[Ultrahydrophobic Self-cleaning Materials & Surfaces]]>, 01 Mar 2011 12:57:06 GMTcontactcurf@clemson.edu Signal Processing Method To Assess Dynamic System Similarity technology features a robust technique to detect dynamic similarity of two systems based on the statistical properties of their signals. The invention assesses the entire autocorrelation structure of a test and a reference signal series. This is achieved in three steps 1) the test and reference signals are subjected to similar pre-processing to guarantee statistical stationarity; 2) the multivariate periodograms or autocovariance functions are calculated for each series; 3) time- and frequency-domain signal discrimination test statistics are computed and assessed. Equality of the test and...Tue, 22 Feb 2011 06:19:47 GMTcontactcurf@clemson.edu Filtration Fabric technology features fibrous activated materials that can remove and /or deactivate potentially dangerous agents from a gas or an air stream. This technology also features methods of forming such fibrous activated materials. These materials are multi-layered that includes one or more fibrous nonwoven interceptor layers and one or more active layers immediately adjacent the interceptor layer. The interceptor layer is a fibrous membrane of very low basis weight, small in size and defines a relatively low porosity. The active layer includes a functional chemistry that can collect, adhere, or ...Tue, 22 Feb 2011 06:19:45 GMTcontactcurf@clemson.edu Fiber Systems and Methods, 01 Feb 2011 08:36:19 GMTcontactcurf@clemson.edu Integrated Picosecond Pulse Generation Circuit invention features an on-chip picosecond pulse generator that can be implemented using complementary metal-oxide-semiconductor (CMOS). The transmission line, the switching device, and the trigger circuit are located on a common semiconductor substrate (CMOS) using standard CMOS technology. The pulse width and amplitude of the output pulse can be modified using the length of the transmission line and on the charging voltage applied to the transmission line. Additional components can be provided on the common semiconductor substrate or chip to shape the input pulse to the switching device t...Fri, 07 Jan 2011 07:31:32 GMTcontactcurf@clemson.edu Colloid Based, Color Tailorable Organic Light-Emitting Diode, 30 Dec 2010 07:28:55 GMTcontactcurf@clemson.edu Polymer Inks nanoparticles and carbon black particles have been used previously as the conducting phase in inks for the printing market due to their high conductivity. Polymeric conductive materials can alleviate the high-cost burden of metals but have had significant problems with solubility and some resulting in lower than desirable conductivities. The technology discussed herein solves both of these barriers. The electrochemical ink in this conducting polymer colloidal nanocomposite invention includes a dispersion of colloidal nanocomposite particles in liquid carrier. The ink can utilize an...Thu, 30 Dec 2010 07:28:50 GMTcontactcurf@clemson.edu Fluid Explosion Process for Removing Lipids from Biomass fossil fuels with sustainable, renewable fuels is a topic of major research, interest, and investment of late. A promising replacement for petro-diesel fuel (which could in turn replace gasoline in many applications) is bio-diesel fuel made from algae, fungus, or plant material. Of these sources, algae shows the greatest potential, but is restrained by the difficulty of extracting the lipids from the cells. Current methods are energy or solvent intensive, and make algae nonviable economically. They include organic solvent extraction, vacuum distillation, and maceration, all of which ...Tue, 28 Dec 2010 13:22:35 GMTcontactcurf@clemson.edu and Electrolyte Materials for Li-ion Batteries (09-009), 15 Dec 2010 13:32:52 GMTcontactcurf@clemson.edu Arc-Flash Determination Device (IADD), 15 Dec 2010 11:43:51 GMTcontactcurf@clemson.edu for Bonding Metal Injection Molded Parts to Conventional Substrate Using Controlled Surface Microstructure, 05 Nov 2010 09:45:00 GMTcontactcurf@clemson.edu Process for a Mono-Domain Hexagonal Array of Standing Nanopillars with Large Diameter and Interpillar Distance, 04 Nov 2010 13:38:55 GMTcontactcurf@clemson.edu for Stabilization and Preservation of Iron Artifacts formation on marine archaeological artifacts is a commonly occurring problem. When these artifacts are recovered from a saltwater environment, the high concentration of chloride ions (Cl-) rapidly oxidizes the metal in the presence of highly-oxygenated air. Placing artifacts in solution, even that similar to the conditions from which artifacts were recovered, will not guarantee long-term cessation of the oxidation process. Conventional treatment for corroded cast and wrought iron is a time-intensive operation that often takes many months or even years, requiring large amounts of chemicals...Thu, 14 Oct 2010 07:20:28 GMTcontactcurf@clemson.edu Structures for Nanoelectronics and Molecular Electronics Characterizations, 24 Jun 2010 07:44:47 GMTcontactcurf@clemson.edu Spectrometers with Planar Nanofluidic Channels, 15 Dec 2009 11:36:43 GMTcontactcurf@clemson.edu Effects of Hyaluronan Oligosaccharides and Their Applications in Tissue Engineering (includes 07-054) is a critical component in all connective tissue and is not readily regenerated by the body. In order to develop or regenerate functional connective tissue, elastogenic cues to synthesize, organize, and stabilize the extracellular matrix are critical.The invention includes novel elastogenic cues for injured or developing connective tissues (i.e. cardiovascular, dermal, pulmonary, and other elastin containing tissue) that will encourage the development of functional and structurally sound tissues. These cues include hyaluronan fragments and oligomers, optionally in conjunction with grow...Tue, 15 Dec 2009 11:02:04 GMTcontactcurf@clemson.edu of Nanocrystalline Calcite on Metal Alloys by a Cellular Biomineralization Means and process for Preparing Same technologies feature a method for deposition of nano-crystalline calcite plates by specialized epithelial tissue or cells onto metallic surfaces, such as stainless steel or other alloys. This is the first demonstration of a novel crystalline material that is produced by animal tissues which can be produced in a highly controlled process. This material and its process for preparation is potentially applicable for producing novel biomaterials for organ and tissue regeneration, biocompatible implants for tissue repair, and bone and joint implants. These materials may be included in the next...Tue, 15 Dec 2009 11:01:58 GMTcontactcurf@clemson.edu Wicking Fiber Bundles for 3-D Tissue Engineering Systems invention is an enhancement to an engineered tissue system that may be used in drug discovery, vaccine development, biomaterial development or developmental cell biology. The enhancement allows biologically relevant tissues to be grown ex vivo. This invention uses lobed/channeled fibers, where lobed/channeled indicates a non-circular cross-section that allows fluid movement along the fiber in a 3-dimensional tissue system to improve transfer of nutrients, waste products and growth factors. The addition of these specialized fibers allows the movement of fluids through a gel environment and...Mon, 14 Dec 2009 13:25:30 GMTcontactcurf@clemson.edu Treatment of Polymeric and Inorganic Surfaces, 14 Dec 2009 09:33:43 GMTcontactcurf@clemson.edu Integrated Dual Site-Specific Recombination System For Use In Developing Environmentally Safe and Clean Transgenic Turfgrass technology presents a novel method of producing a transgenic hybrid plant having no or reduced sexual reproduction. This technology features the use of multiple site-specific recombination systems for use in transgene containment in plants. More specifically, this technology presents coordinated excisional DNA recombination by multiple (e.g. dual) recombinases to achieve excision of unwanted transgenic DNA as well as recombinase-coding sequences themselves by self-excision. Furthermore, the simultaneous use of multiple site-specific recombination systems in combination with controllable t...Fri, 11 Dec 2009 09:08:55 GMTcontactcurf@clemson.edu Microbiological-based Chlorinated Ethene Destruction is an innovative treatment technology for the containment, detoxification and elimination of chlorinated ethenes (CE) in the environment. MicroCED consists of several novel microorganisms that are new to science. MicroCED rapidly and completely converts CE to non-toxic, safe end products without production or accumulation of toxic by-products. MicroCED can detoxify both saturated and unsaturated CE and is amendable for treatment of mixtures of these pollutants. MicroCED is a sensitive and efficient bio-process for CE. MicroCED is versatile; it can be used as a low cost, low maintenanc...Fri, 11 Dec 2009 09:08:54 GMTcontactcurf@clemson.edu Transduction Biology Based Marine Antifouling Coating technology features a novel method of deterring biofouling of a surface, the undesirable accumulation of micro-organism, plants, algae and animals on submerged structures or other structures exposed to water or damp environments. Current anti-fouling coatings that have biocidal effects are copper based and there is concern that leached copper is detrimental to the marine environment. This technology features a treatment with noradrenalin (NA) which only disrupts larval settlement and does not harm the organism's growth or survival. Attaching themselves to surfaces, organisms not only impe...Fri, 11 Dec 2009 08:50:38 GMTcontactcurf@clemson.edu Screening Model for Adverse Drug Reactions, 11 Dec 2009 08:50:37 GMTcontactcurf@clemson.edu Colorimetric Test for Quantification of Uranium in Drinking Water technology features novel methods, materials and systems to determine the uranium concentration in water samples. These methods generally include a concentration step and a complexation step. Uranium concentration can be carried out according to an extraction chromatographic process and complexation can chemically bind uranium with a detectable substance such that the formed substance is visually detectable. These methods can detect uranium contamination down to levels even below the maximum contamination level (MCL) as established by the EPA. These systems are relatively simple and cost-...Thu, 10 Dec 2009 10:08:26 GMTcontactcurf@clemson.edu Hydrogel System for the Treatment of Stroke and Nervous Tissue Injury, 10 Dec 2009 09:12:50 GMTcontactcurf@clemson.edu Organically Certifiable Method of Producing Ammonium Nitrate for Fertigation of Organic Vegetable Production technology features a novel approach to forming ammonia and/or ammonium that does not use nonrenewable resources as starting or intermediate materials and that does not require the use of any synthetic or hazardous compounds. Also featured are the bioreactors used to carry out these methods. This approach features an environmentally friendly method for producing ammonia and ammonium necessary for many applications, including organic farming. Demand continues to grow for organically grown produce due primarily to the high nutritional quality of the produce and the ability to keep soils and...Thu, 10 Dec 2009 08:16:50 GMTcontactcurf@clemson.edu the Injection Well Saturation of Carbon Dioxide in Water for Geologic Storage technology features an apparatus and a process for the capture and storage of carbon dioxide gases in subsurface aquifers. These novel injection well components and well design promote rapid dissolving of carbon dioxide into water derived from distant extraction well fields. Carbon dioxide has a high solubility in water, and at higher hydrostatic pressure the solubility is increased to a maximum at depths of around 2000 feet below the aquifer surface. Water becomes more dense with higher dissolved carbon dioxide. Greater density makes the water negatively buoyant and a competent cap lock/...Thu, 10 Dec 2009 06:58:00 GMTcontactcurf@clemson.edu