Scrybe: Blockchain Ledger for Clinical Trials

Market Overview:

Scrybe utilizes Lightweight Mining (LWM) which allows the algorithm to depart from the

resource-intensive and time-consuming verification approaches that cryptocurrencies use when

expanding the blockchain. The clinical trials market size is expected to reach 68.9 billion by

2026, growing with a CAGR of 5.7%. Digitization is rapidly being adapted by securely maintaining

patient data records, which lowers cost and reduces process errors. Ensuring that trial data is

securely stored is essential to meet stringent regulations from governing bodies like the FDA.

Scrybe also prevents malicious manipulation of data and is not dependent on local policy. This

allows auditors to verify the integrity of the stored data, and the data integrity and non-

repudiation are guaranteed. 


Application                                                   Stage of Development

Clinical trials, information security,               Ready for Licensing

data management                    



•  All data is digitally signed ensuring integrity and allowing it to be tracked

• Improved energy efficiency and lower cost

• Can tolerate a larger percentage of malicious actors 


Technical Summary

Scrybe has two main components: blocks and transitions. Blocks are added to the

blockchain by authorized miners. Transactions can reference previous transactions,

providing a chain of custody, or they can be genesis events, which register the acquisition

of new data. Both patient information and permissions are collected and stored on a local

server controlled by the medical institution. Using non-sensitive meta-data, a transaction is

created on the secure server and a permanent universal resource locator (PURL) is created

pointing to the data. The transaction is signed and submitted to miners. These miners add

the transaction to a block which is then added to the blockchain where it can be broadcast

to other miners for verification. Raw data is collected and stored locally on a secure server.

This process is repeated as more information is generated and subsequently associated

with the original transaction. This allows auditors and researchers to access the findings of

other teams by viewing transaction records within the blockchain complete with signature

for data verification.


View printable PDF version of this technology


Inventor:                        Dr. Robert Brooks


Patent Type:                 


Serial Number:              N/A


CURF Ref No:              2018-035




Patent Information:
For Information, Contact:
Andy Bluvas
Technology Commercialization Officer
Clemson University Research Foundation
Tony Skjellum
Lu Yu
Computer Software
Cyber-Security/Security Systems
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