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Myocardial In Vitro Platform for Drug Development and Cardiotoxicity Screening

This myocardial in vitro screening platform provides relevant physiological stimuli enabling analysis of output metrics with direct clinical relevance to cardiac function. While drug discovery is robust and well-funded, a very low percentage of experimental drug candidates reach the marketplace as FDA-approved therapies. This translates into billions...

Published: 10/8/2024 | Inventor(s): William Richardson, Samuel Coeyman, Jonathan Heywood

Keywords(s): Analytical/Diagnostics/Instru./Sensors-Medical/Biological, Biomaterials - Cardiovascular, Cardiovascular, Diabetes, Drugs/Pharma - Antibiotics, Drugs/Pharma - Drug Delivery, Drugs/Pharma - HIV/Cancer/Other, Medical Device, Molecular Therapies, Oncology/Cancer, Regenerative Medicine, Tissue Engineering

Category(s): Biomedical Sciences

Performance Lab Testing for Evaluating Faceguard Effectiveness

This novel faceguard test determines the structural stiffness for all newly manufactured facemasks, serving to reduce head injuries among athletes due to the use of inadequately performing protective gear. In response to the high rate of severe traumatic brain injury and skull fracture during football play, in 1974 the National Operating Committee for...

Published: 10/8/2024 | Inventor(s): Alexander Bina, John DesJardins, Gregory Batt

Keywords(s): Analytical/Diagnostics/Instru./Sensors-Medical/Biological, Analytical/Instrumentation/Sensors-Non-Medical/NonBiological, Athletic Equipment

Category(s): Information and Communication Technology

Capillary-Channeled Polymer Fibers for Isolating Exosomes

This capillary-channeled polymer (C-CP) fiber technology is a cost efficient and highly selective method to isolate exosomes facilitating widespread use of these cellular fragments for biomarker research, medical diagnostics, and targeted delivery of therapeutics. Exosomes are lipid membrane-derived vesicles secreted by most types of cells, which hold...

Published: 10/8/2024 | Inventor(s): Richard Marcus, Terri Bruce, Lei Wang, Sisi Huang, Tyler Slonecki, Rhonda Powell

Keywords(s): Analytical/Diagnostics/Instru./Sensors-Medical/Biological, Bioprocessing/Biotechnology, Drugs/Pharma - Drug Delivery

Category(s): Advanced Materials, Biomedical Sciences

Carbon Nanotube Composite for Use in Conductive MEMS Devices (2016-031)

This composite, made of multi-walled carbon nanotubes (MWNT) and cellulose nanocrystals (CNC), provides a safer substitute for silicon in microelectromechanical system (MEMS) devices. The global MEMS market was $11.9 billion in 2015, and is expected to grow to $18 billion by 2020 due to increased interest in wearable technology and the automotive industry....

Published: 10/8/2024 | Inventor(s): Christopher Kitchens, Byron Villacorta, Mingzhe Jiang

Keywords(s): Analytical/Diagnostics/Instru./Sensors-Medical/Biological, Analytical/Instrumentation/Sensors-Non-Medical/NonBiological, Electronics Parts/Manufacturing, Nanotechnology

Category(s): Advanced Materials

Organic Fluorophores for More Efficient Plastic Scintillators (2016-019)

These organic fluorophores have enhanced luminosity in response to ionizing radiation, increasing the efficiency of plastic scintillators and providing greater environmental stability. With increasing investments in radiation monitoring for homeland security, the scintillator market is expected to reach $607.21 Million by 2025. Currently available plastic...

Published: 10/8/2024 | Inventor(s): Valery Bliznyuk, Ayman Seliman, Timothy Devol, Nadezhda Derevyanko, Alexander Ishchenko

Keywords(s): Analytical/Diagnostics/Instru./Sensors-Medical/Biological, Medical Device, Optical Fibers/Materials/Other

Category(s): Advanced Materials

Improved High-Density Functionality of Polymer Surfaces (2015-044)

This easy modification creates polymer surfaces with high-density functionality by using polyethylene terephthalate (PET) capillary-channeled polymer (C-CP fibers) as the support material. The low-cost modification provides the capability for fast protein separations for proteomics applications and downstream processing due to the improved binding capacity....

Published: 10/8/2024 | Inventor(s): Richard Marcus, Liuwei Jiang

Keywords(s): Analytical/Diagnostics/Instru./Sensors-Medical/Biological

Category(s): Advanced Materials

Portable EPR Sensors

This invention will be used to exploit electron-paramagnetic-resonance (EPR) as a new approach for rapid diagnostic tests (RDTS) of malaria. The idea is to use RF interference processes to boost EPR sensor sensitivity by more than 103 times for rapid characterization of malaria pigment hemzoin in a single parasitized red-blood-cell (RBC) in blood-plasma....

Published: 10/8/2024 | Inventor(s): Pingshan Wang, Yuxi He, David Moline, Jiwei Sun, Yan Cui

Keywords(s): Analytical/Diagnostics/Instru./Sensors-Medical/Biological

Category(s): Biotechnology

Functionalized Modification of Polymers for HPLC

These polymer fibers, used as stationary phases in high-performance liquid chromatography (HPLC), enable a high level of selectivity and throughput, thus increasing efficiency. Chromatography is a method used by scientists to separate organic and inorganic compounds for further analysis. Currently, over 60% of chemical analysis worldwide is done in...

Published: 10/8/2024 | Inventor(s): Kenneth Christensen, Richard Marcus

Keywords(s): Analytical/Diagnostics/Instru./Sensors-Medical/Biological, Bioprocessing/Biotechnology, Polymers/Composites, Textiles/Fibers - Non-Optical/Medical/Other

Category(s): Biotechnology

Fiber Bundle Cartridges as Chemical Separation Media

Monolithic cartridges including a plurality of nominally aligned polymer fibers can be used as stationary phase materials for liquid chromatography separations. Bundles of fibers are packed together so as to form capillary channels between the fibers. Different polymer compositions permit the “chemical tuning” of the separation process....

Published: 10/8/2024 | Inventor(s): Richard Marcus, Rayman Stanelle, Igor Luzinov, Philip Brown, Yonnie Wu

Keywords(s): Analytical/Diagnostics/Instru./Sensors-Medical/Biological, Analytical/Instrumentation/Sensors-Non-Medical/NonBiological, Bioprocessing/Biotechnology, Textiles/Fibers - Non-Optical/Medical/Other

Category(s): Advanced Materials

Nanofibers for Probing Hazardous Liquids (2012-024)

These porous nanofibers are designed to collect extremely small volumes of liquid for analysis, featuring materials that control liquid uptake by a butterfly-type proboscis. The global nanofibers market had an estimated worth of $390.6 million, and is expected to grow at over a 25% CAGR between 2016 and 2024 due to the ever-expanding application space....

Published: 10/8/2024 | Inventor(s): Konstantin Kornev, Chen-Chih Tsai, David Lukas, Petr Mikes

Keywords(s): Analytical/Diagnostics/Instru./Sensors-Medical/Biological, Analytical/Instrumentation/Sensors-Non-Medical/NonBiological, Nanotechnology, Textiles/Fibers - Non-Optical/Medical/Other

Category(s): Advanced Materials

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