Portable EPR Sensors

Market Overview:

This invention will be used to exploit electron-paramagnetic-resonance (EPR) as a new approach for rapid diagnostic tests (RDTS) of malaria. The idea is to use RF interference processes to boost EPR sensor sensitivity by more than 103 times for rapid characterization of malaria pigment hemzoin in a single parasitized red-blood-cell (RBC) in blood-plasma.

The proposed idea is unconventional because (i) it is a resonator-less method that boosts EPR sensor sensitivity and time-resolution by orders of magnitude with liquid samples, (ii) it enables multi-frequency EPR scheme to significantly enhance EPR information contents, and (iii) EPR has not been used for malaria diagnostics. These EPR sensors are expected to be quantitative, accurate, portable, easy to operate, and rugged to deploy. Compared with current EPR spectrometer techniques, these EPR sensors are expected to be orders-of-magnitude more sensitive with sub-millisecond time-resolutions. Also, compared with the recent magneto-optic technology (MOT) detection approach, our quantitative method has single-cell sensitivity.

Applications:

· Clinical diagnoses of malaria

· EPR systems as chemistry instruments

Benefits:

· Non-invasiveness

· Portability

· More sensitive than current EPR techniques

· Low cost

 

Inventors:                        Pingshan Wang, Yuxi He, David Moline, Jiwei Sun

Protection Status:           Patent application filed

Licensing Status:            Available for licensing

CURF Ref No:                2012-053

 

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Patent Information:
Category(s):
Biotechnology
For Information, Contact:
Andy Bluvas
Technology Commercialization Officer
Clemson University Research Foundation
bluvasa@clemson.edu
Inventors:
Pingshan Wang
Yuxi He
David Moline
Jiwei Sun
Yan Cui
Keywords:
Analytical/Diagnostics/Instru./Sensors-Medical/Biological
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