Elastin Targeted Drug Delivery for Treating Elastin Degenerative Diseases (2012-048)

Market Overview:

This targeted drug delivery approach uses micro-sized drug carriers with elastin antibodies that recognize, attach, and deliver compounds to prevent enzymatic degradation of elastin in diseased tissue. Enzymatic degradation of elastin tissue is the primary cause of chronic obstructive pulmonary disease (COPD) and abdominal aortic aneurysm (AAA). COPD is the third leading cause of death in the U.S. and there are over 3 million new cases of AAA each year. Currently, damaged elastin is managed via surgical procedures like endovascular surgery. While most procedures are minimally invasive, its lifespan has yet to be determined and does not directly improve the condition of elastic tissue at the damaged site. Clemson University researchers have developed drug carriers designed to target damaged elastin by a simple IV injection. The elastin antibody drug carriers bind to exposed elastin and deliver therapeutic compounds to preserve and regenerate elastin tissue.

Application                                                                                               Stage of Development

Treating COPD, cardiovascular aneurysms; elastin regeneration             In vivo animal studies

Advantages

• Targets extracellular matrix proteins and not cellular proteins, boosting efficacy and minimizing systemic effects

• Inhibits or reverses progression of elastin degeneration, overcoming barriers of current treatments

Technical Summary

This approach utilizes drug-loaded nanoparticles coated with elastin antibodies to correct and prevent elastin degradation. These particles are coated with receptors that bind specifically to damaged or exposed elastin molecules, thus increasing the residence time of the particles inside the body and improving the drug efficacy at the degeneration site. The particles also release a polyphenol (PGG) that works to prevent degradation from occurring while also regenerating elastic tissue.  These particles can be delivered intravenously, marking a significant advantage over surgical treatments. The approach demonstrates effectiveness in targeting in vivo in number of animal models of the diseases such as AAA, COPD, arteriosclerosis, and skin disorders.

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Inventors:                        Naren Vyavahare, Aditi Sinha

Patent Type:                    Utility

Serial Number:                13/929,140

CURF Ref:                      2012-048

 

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Patent Information:
Category(s):
Biomedical Sciences
For Information, Contact:
Chris Gesswein
Director of Licensing
Clemson University Research Foundation
agesswe@clemson.edu
Inventors:
Narendra Vyavahare
Aditi Sinha
Keywords:
Biomaterials
Cardiovascular
Cardiovascular Biomaterials
Drugs / Pharma
Medical Device
Molecular Therapies
Nanoscale Drug Delivery
Regenerative Medicine
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