Stable Antibacterial Albumin Coating for Medical Devices and Implants

Market Overview:

Healthcare-Associated Infections (HAIs) characterized by antibiotic resistance, represent a global medical challenge tha claims billions of dollars of healthcare expenditures. Procedures involved tubes inserted into the body (i.e. catheterization) are among the primary causes of HAIs.  Presented here is a stable antibacterial coating for intubation devices, and other temporary or permanent devices, that aim to prevent HAIs by preventing bacterial adhesion, biofilm formation, and bacterial antibiotic resistance. 

Albumin has long been utilized as a surface coating that prohibits non-specific adsorption of organic materials and microorganisms. However, the success of physically absorbed albumin produced from solution in the prevention of bacterial colonization and biofilm formation has been limited due to the poor stability of albumin at the surfaces. As a result, physically absorbed albumin coatings often fail in in vivo applications. Recently, a novel strategy to derive plasticized coating from albumin has been developed. The coating is resistant to desorption and proteolytic degradation while retaining the ability to prevent bacteria adhesion and biofilm formation. In vivo tests indicate that the albumin plastics are robust and stable for up to four months and are capable of long term, progressive drug, growth factor, or antibacterial agent release. 

Applications: 

· Anti-bacterial coating for medical devices  (catheters, intubation devices, guide wires)

· Coatings featuring slow degrading drug release profile (orthopedic implants, sutures, meshes, stents)

Benefits:

· Robust and stable coating to inhibit bacteria adhesion, colonization and biofilm formation

· Reduce chance of  Healthcare-Associated Infections and their associated subsequent costs

· Could mitigate the overuse and abuse of bactericidal agents

· Improves biocompatibility of implanted devices

 

Inventors:                          Igor Luzinov, Xuejun Wen, Suraj Sharma

Protection Status:             Patent application filed

Licensing Status:              Available for licensing

CURF Ref No:                  08-067

 

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Patent Information:
Category(s):
Biomedical Sciences
For Information, Contact:
Andy Bluvas
Technology Commercialization Officer
Clemson University Research Foundation
bluvasa@clemson.edu
Inventors:
Igor Luzinov
Xuejun Wen
Suraj Sharma
Ben Whatley
Keywords:
Biomaterials
Biomaterials Implant Design
Coatings
Medical Device
Molecular Therapies
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