Treatment to Render Implants Resistant to Diabetes

Market Overview:

Diabetes plays a role in the functionality of biomaterials in the body.  Hyperglycemia, the condition arising from high blood sugar levels, causes occlusion and restenosis of vascular grafts and degeneration of heart valves.  These conditions lead to heart disease, which made up 68% of all diabetes-related deaths in the U.S. in 2004[1].  A primary problem associated with hyperglycemia is the presence of advanced glycosylation end products (AGEs) in the bloodstream.  These molecules induce crosslinking of collagen and elastin, thus increasing heart valve stiffness and consequently reducing their efficacy in the body.

This technology from Clemson University introduces a novel method of treating biomaterials with a polyphenol to improve the effectiveness and lifespan of cardiovascular implants in diabetic individuals.  Collagen and elastin scaffolds treated with pentagalloyl glucose (PGG) have shown that they are able to withstand the detrimental effects of AGEs.  PGG also protects against glycoxidation and inflammation, and promotes scaffold remodeling by native fibroblasts.  This simple treatment marks a significant improvement in the area of cardiovascular healthcare for diabetic patients.


· Treatment of biomaterials with diabetic-resistant coating

· Scaffold stabilizer for regenerative medicine

· Wound dressing

· Anti-aging products


· Reduces effects of AGEs

· Protects against oxidative stress and inflammation

· Promotes fibroblast remodeling


Related Publications:

· Agneta Simionescu et al. “Mitigation of diabetes-related complications in implanted collagen and elastin scaffolds using matrix-binding polyphenol.” Biomaterials.  Vol. 34. Issue 3. Pg. 685-695. Jan 2013


Inventors:                        Agneta Simionescu, Dan Simionescu, James Chow

Protection Status:           Patent application filed

Licensing Status:            Available for licensing

CURF Ref No:                2012-057


[1] (2011) Centers for Disease Control and Prevention


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Patent Information:
Biomedical Sciences
For Information, Contact:
Alan Alfano
Technology Commercialization Officer
Clemson University Research Foundation
Agneta Simionescu
Dan Simionescu
James Chow
Biomaterials - Cardiovascular
Medical Device
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