Search Results - Cardiovascular Biomaterials

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Elastin Targeted Drug Delivery for Treating Elastin Degenerative Diseases (2012-048)
This targeted drug delivery approach uses micro-sized drug carriers with elastin antibodies that recognize, attach, and deliver compounds to prevent enzymatic degradation of elastin in diseased tissue. Enzymatic degradation of elastin tissue is the primary cause of chronic obstructive pulmonary disease (COPD) and abdominal aortic aneurysm (AAA). CO...
Published: 9/13/2016   |   Inventor(s): Narendra Vyavahare, Aditi Sinha
Keywords(s): Biomaterials, Cardiovascular, Cardiovascular Biomaterials, Drugs / Pharma, Medical Device, Molecular Therapies, Nanoscale Drug Delivery, Regenerative Medicine
Category(s): Biomedical Sciences
Bioprosthetic Heart Valves that Resist Structural Degradation and Stiffening (2013-055)
This treatment stabilizes the connective tissue present in bioprosthetic heart valves to create durable and long-lasting replacement heart valves. There are approximately 300,000 heart valve transplantations performed globally each year and heart valve disorders are diagnosed in approximately four million people. There are major problems with the t...
Published: 6/3/2016   |   Inventor(s): Narendra Vyavahare, Hobey Tam
Keywords(s): Cardiovascular Biomaterials, Molecular Therapies
Category(s): Biomedical Sciences
Treatment to Render Implants Resistant to Diabetes
Diabetes plays a role in the functionality of biomaterials in the body. Hyperglycemia, the condition arising from high blood sugar levels, causes occlusion and restenosis of vascular grafts and degeneration of heart valves. These conditions lead to heart disease, which made up 68% of all diabetes-related deaths in the U.S. in 2004[1]. A primary ...
Published: 1/17/2013   |   Inventor(s): Agneta Simionescu, Dan Simionescu, James Chow
Keywords(s): Biomaterials, Biomaterials Implant Design, Cardiovascular Biomaterials, Drugs / Pharma, Medical Device, Molecular Therapies, Regenerative Medicine
Category(s): Biomedical Sciences
Elastogenic Effects of Hyaluronan Oligosaccharides and Their Applications Thereof in Tissue Engineering (includes 07-054)
Elastin is a critical component in all connective tissue and is not readily regenerated by the body. In order to develop or regenerate functional connective tissue, elastogenic cues to synthesize, organize, and stabilize the extracellular matrix are critical.The invention includes novel elastogenic cues for injured or developing connective tissues ...
Published: 12/15/2009   |   Inventor(s): Anand Ramamurthi, Chandrasekhar Kothapalli, Binata Joddar
Keywords(s): Biomaterials, Cardiovascular Biomaterials, Medical Device, Molecular Therapies, Tissue Engineering
Category(s): Biomedical Sciences
Improved Fixation Method for Bioprosthetic Heart Valves
This technology features a novel improvement of bioprosthetic heart valves (BHVs). This technology is a new method for fixation of BHVs derived from porcine aortic valves. BHVs are used clinically to replace defective or diseased heart valves, but a majority of these valves fail within a few years due to calcification and degeneration. Currently us...
Published: 12/14/2009   |   Inventor(s): Narendra Vyavahare, Devanathan Raghavan
Keywords(s): Cardiovascular Biomaterials, Medical Device, Treatment Method
Category(s): Biomedical Sciences
New Material for Transcatheter Bioprosthetic Heart Valves
This technology features a biomaterial useful for bioprostheses, such as bioprosthetic heart valves (BHVs), in which the fixed tissue has improved elastic properties. The high elastin-containing biomaterial is further characterized by having anisotropic properties wherein the biological material has a greater stiffness in one direction and a greate...
Published: 12/14/2009   |   Inventor(s): Narendra Vyavahare, Dan Simionescu
Keywords(s): Biomaterials, Cardiovascular Biomaterials, Medical Device, Treatment Method
Category(s): Biomedical Sciences
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