Enhanced Color Sensitivity for Colorimetric-based Chemical Analysis (2017-055)

Market Overview:

This novel technology for colorimetric chemical analysis significantly enhances color change intensity and uniformity upon exposure to a target substance when compared to conventional color-indicating substrates. This technology thus has application to any colorimetric-based chemical assay, such as urinalysis. The global urinalysis market was estimated to be 1.37 billion USD in 2015 and has only continued to grow since then. As one example for its application, this invention has potential to greatly impact the diagnoses and monitoring of phenylketonuria (PKU), an inborn metabolic disorder that results in decreased metabolism of the amino acid phenylalanine (Phe) and affects about 1 in 10,000 individuals. Most countries screen newborns for PKU as it can lead to brain damage, intellectual disabilities, and seizures when left untreated, but populations in developing regions may lack access to the necessary infrastructure for testing. Clemson University researchers have developed a technology that has the capability to not only improve upon conventional color-indicating substrates for urinalysis, but also to reduce the frequency, high cost, and discomfort of collecting the blood samples that are currently required for monitoring blood Phe levels for individuals with PKU. With further development, this invention could also potentially be used as a urine test to monitor diabetes and kidney function, or essentially for any colorimetric chemical or biochemical assay to provide enhanced sensitivity, color uniformity, and at lower limits of detection.

 

Application                                                             Stage of Development

Testing of chemical and biochemical agents           Preliminary prototype

 

Advantages

•       Enhanced color change intensity and uniformity, making test results easier to interpret

•       Greater color-change sensitivity, ensuring accurate results

•       Manufactured from relatively inexpensive materials, reducing product costs

 

Technical Summary

This novel coupon design significantly improves color change intensity and uniformity upon exposure to a target analyte in a test solution. This coupon consists of an absorbent disk with the outside dimension ranging from a few millimeters to tens of millimeters. The coupons can be made out of a layer of absorbent material, such as cotton or cellulose, with a central hole up to several millimeters in diameter formed perpendicular to the surface plane of the coupon. By this design when exposed to a test liquid, the cavity is capable of trapping and holding a column of liquid by a combination of surface tension from the liquid and the wicking properties of the absorbent coupon material itself.  The cavity, which supports a column of the test liquid, is where the enhancement of the color change and color uniformity is observed when

compared to the color change in the absorbent material of the coupon. This novel coupon design has been developed in conjunction with colorimetric analysis methods for the testing of analytes in liquids using digital photography under controlled lighting combined with quantitative color interpretation using a numeric color scale, such as the RGB (red-green-blue) color scale, which provides color intensity values between 0 and 255. This method essentially enables chemical spectroscopy to be conducted for the quantitative measurement of the concentration of targeted analytes without the use of expensive laboratory spectroscopy equipment, thus facilitating its use in the field or at home for chemical analysis.

 

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Inventor:                        Dr. Robert Latour

Patent Type:                  Provisional

Serial Number:              62/554,873

CURF Ref No:              2017-055

Patent Information:
For Information, Contact:
Chris Gesswein
Director of Licensing
Clemson University Research Foundation
agesswe@clemson.edu
Inventors:
Robert Latour
George Chumanov
Alexandra Cholewczynski
Keywords:
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